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Séminaire de EDP - Physique Mathématique

Derivation of membrane conditions for a model of tumour invasion

Giorgia Ciavolella

( IMB )

Salle de Conférences

le 16 mai 2023 à 11:00

Studying tumour evolution, a crucial and challenging scenario is represented by cancer cells invasion through thin membranes. In particular, one of the most difficult barriers for cells to cross is the basement membrane. In this talk, we study a porous-medium type equation where the density of the cell population evolves under Darcy's law, assuming continuity of both the density and flux velocity on the thin membrane which separates two domains. The drastically different scales and mobility rates between the membrane and the adjacent tissues lead to consider the limit as the thickness of the membrane approaches zero. We present the main tools to recover the rigorous limit problem which is called effective problem and the transmission conditions on the limiting zero-thickness membrane, formally derived by Chaplain et al. (2019), which are compatible with nonlinear generalized Kedem-Katchalsky ones.