Classical harmonic analysis often relies on the structure of the Euclidean space. It turns out that a good substitute for the Euclidean structure which allows to prove deep results on singular integral operators and is at the same time flexible enough for most applications are homogeneous spaces. I will provide examples why a doubling measure is indeed crucial for lots of arguments in homogeneous spaces. However, already subsets of Euclidean space can lead easily to constellations which are not captured by the framework of homogeneous spaces, take for instance an outward cusp. I will explain how one can show boundedness of singular integral operators related to differential operators on such sets taking advantage of their boundary conditions. To make ideas more accessible, I will begin with the case of pure Dirichlet boundary conditions and only if time allows I will demonstrate how the arguments can be modified to also apply to the case of mixed boundary conditions.