Uncertainty quantification in a safety analysis study can be conducted by considering the uncertain inputs of a physical system as a vector of random variables. The most widespread approach consists in running a computer model reproducing the physical phenomenon with different combinations of inputs in accordance with their probability distribution. Then, one can study the related uncertainty on the output or estimate a specific quantity of interest (QoI). Because the computer model is assumed to be a deterministic black-box function, the QoI only depends on the choice of the input probability measure. It is formally represented as a scalar function defined on a measure space. We propose to gain robustness on the quantification of this QoI. Indeed, the probability distributions characterizing the uncertain input may themselves be uncertain. For instance, contradictory expert opinion may make it difficult to select a single probability distribution, and the lack of information in the input variables inevitably affects the choice of the distribution. As the uncertainty on the input distributions propagates to the QoI, an important consequence is that different choices of input distributions will lead to different values of the QoI. The purpose of this work is to account for this second level uncertainty. We propose to evaluate the maximum of the QoI over a space of probability measures, in an approach known as optimal uncertainty quantification (OUQ). Therefore, we do not specify a single precise input distribution, but rather a set of admissible probability measures defined through moment constraints. In the case where the QoI is a quasi-convex function, it is then optimized over this measure space. After exposing theoretical results showing that the optimization domain of the QoI can be reduced to the extreme points of the measure space, we present several interesting quantities of interest satisfying the assumption of the problem.